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Septic arthritis caused by an emerging ST121 methicillin-susceptible, PVL-negative Staphylococcus aureus harbouring a

A Togashi1, M S Aung2, Y Yoto1

  • 1Department of Pediatrics, Japan.

New Microbes and New Infections
|July 1, 2017
PubMed

Insights

Methicillin-susceptible Staphylococcus aureus ST121/agr-IV was found in septic arthritis patient samples. This strain lacked the PVL gene but possessed a variant bone sialoprotein-binding protein gene.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Staphylococcus aureus is a common cause of infections, including septic arthritis.
  • Specific strains like ST121/agr-IV can cause severe invasive disease.
  • Understanding virulence factors is crucial for treating Staphylococcus aureus infections.

Purpose of the Study:

  • To characterize a methicillin-susceptible Staphylococcus aureus ST121/agr-IV isolate from a septic arthritis patient.
  • To investigate the presence of key virulence genes, including Panton-Valentine leukocidin (PVL).
  • To identify unique genetic features of the isolate.

Main Methods:

  • Bacterial isolation and identification from patient samples (synovial fluid, blood, skin, nasal cavity).
  • Molecular detection of the Panton-Valentine leukocidin (PVL) gene.
  • Analysis of genes encoding virulence factors, specifically bone sialoprotein-binding protein.

Main Results:

  • The ST121/agr-IV Staphylococcus aureus isolate was successfully cultured from multiple sites.
  • The isolate tested negative for the Panton-Valentine leukocidin (PVL) gene.
  • A variant bone sialoprotein-binding protein gene with a shortened SD-repeat region was identified.

Conclusions:

  • The characterized Staphylococcus aureus isolate, despite lacking PVL, possesses a unique genetic variant potentially contributing to its virulence.
  • Further research is needed to understand the role of this variant bone sialoprotein-binding protein in Staphylococcus aureus pathogenesis.
  • This finding highlights the genetic diversity of Staphylococcus aureus strains causing invasive infections.
Keywords:
Bone sialoprotein-binding proteinST121Staphylococcus aureusseptic arthritis

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