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Frequent respiratory viral infections in a young child in a 27-month follow-up study

Atsushi Kaida1, Hideyuki Kubo1, Nobuhiro Iritani1

  • 1Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan.

JMM Case Reports
|July 1, 2017
PubMed

Insights

Young children in group settings frequently get respiratory viruses, especially rhinovirus. Viral genomes can be detected for up to a month using PCR, even during asymptomatic periods.

Area of Science:

  • Pediatrics
  • Virology
  • Infectious Diseases

Background:

  • Respiratory viruses are common causes of illness in young children.
  • Previous studies focused on sporadic cases, with limited longitudinal data on individual children.
  • Understanding viral shedding duration is crucial for infection control in childcare settings.

Purpose of the Study:

  • To determine the frequency of respiratory viral infections in a young child.
  • To investigate the duration of viral genome detection in clinical samples.

Main Methods:

  • Collected 284 nasal swabs from a single child (4-31 months) during symptomatic and asymptomatic periods.
  • Utilized multiplex real-time PCR to test for 19 respiratory viruses.
  • Analyzed viral detection rates and shedding durations.

Main Results:

  • 69.7% of specimens tested positive for respiratory viruses.
  • Rhinovirus was the most frequently detected virus (26 instances).
  • Viral genomes were detected for extended periods: human coronavirus NL63 (30 days), rhinovirus (28 days), and human bocavirus 1 (22 days).

Conclusions:

  • Children in group settings, like nursery schools, face a high risk of respiratory virus infections.
  • Rhinovirus is a predominant pathogen in this population.
  • Viral genomes can persist for approximately one month, as detected by PCR.
Abstract

Keywords:
detection durationfrequencynursery schoolrespiratory virus infectionyoung children

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