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Candida Albicans Dural Granuloma: Case Report.
Alessandro Di Rienzo1, Maurizio Iacoangeli1, Niccolò Nocchi1
1Department of Neurosurgery, Universita' Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy.
NMC Case Report Journal
|July 1, 2017
Summary
A rare case of Candida albicans granuloma exclusively within the dura mater was successfully treated with surgery and antifungal therapy. This unique presentation highlights the importance of prolonged observation for potential complications.
Area of Science:
- Neurology
- Infectious Diseases
- Surgical Pathology
Background:
- Candida albicans can disseminate to the central nervous system (CNS) in immunocompromised individuals.
- Intracerebral lesions are common, but meningeal or cerebrospinal fluid involvement is rare.
- This case presents a unique intradural granuloma, distinct from typical CNS candidiasis.
Observation:
- A 75-year-old male with a history of Candida albicans urinary sepsis presented with acute neurological deficits.
- Imaging revealed a large fronto-parietal mass causing significant brain compression.
- The lesion was surgically excised and pathologically confirmed as an intradural Candida albicans granuloma.
Findings:
- Complete surgical removal of the intradural granuloma was achieved.
- Post-operative antifungal therapy was initiated.
- The patient experienced an uneventful recovery from surgery but later developed a bone flap infection requiring further intervention.
Implications:
- Isolated intradural Candida albicans granuloma is a previously undescribed entity.
- Surgical excision can resolve mass effect, but prolonged follow-up is crucial.
- Potential for delayed complications, such as bone flap infection, necessitates vigilant monitoring.
