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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

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Role of red grape polyphenols as antidiabetic agents

Kanti Bhooshan Pandey1, Syed Ibrahim Rizvi1

  • 1Department of Biochemistry, University of Allahabad, Allahabad, India.

Integrative Medicine Research
|July 1, 2017
PubMed

Insights

Polyphenols like quercetin, myricetin, and resveratrol from red grapes may help prevent diabetic complications. These natural compounds combat oxidative stress, a key factor in hyperglycemia and its damaging effects.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Nutritional Science

Background:

  • Diabetes mellitus incidence is rising globally, leading to severe health complications.
  • Persistent hyperglycemia contributes to damage in vital organs like the retina, brain, and kidneys.
  • Oxidative stress is a critical factor in the development and progression of diabetic complications.

Purpose of the Study:

  • To review the role of major red grape polyphenols (quercetin, myricetin, resveratrol) in mitigating diabetic complications.
  • To provide an update on their comparative efficacy.
  • To highlight the molecular mechanisms of oxidative stress in hyperglycemia.

Main Methods:

  • Literature review focusing on studies of quercetin, myricetin, and resveratrol.
  • Analysis of research on oxidative stress and hyperglycemia.
  • Comparative assessment of polyphenol efficacy against diabetic pathologies.

Main Results:

  • Quercetin, myricetin, and resveratrol show potential in preventing or managing diabetic complications.
  • These polyphenols exert protective effects through mechanisms related to oxidative stress.
  • Evidence supports their role in combating hyperglycemia-associated pathologies.

Conclusions:

  • Red grape polyphenols offer a promising natural approach to managing diabetes complications.
  • Targeting oxidative stress is a key strategy for intervention.
  • Further research into these compounds could lead to novel therapeutic strategies.
Keywords:
diabeteshyperglycemiaoxidative stresspolyphenols

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