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Postinflammatory hyperpigmentation after human cold pain testing.

Melissa J Wolz¹, Katelyn E Sadler¹, Caela C Long¹

¹Department of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.

|July 1, 2017

Summary

This summary is machine-generated.

We developed a low-cost method to measure cold pain thresholds. A rare side effect of prolonged skin discoloration was observed, raising safety concerns for this thermal sensitivity assay.

Keywords:

Adverse event Cold pain Human testing Hypersensitivity Postinflammatory hyperpigmentation

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Area of Science:

Neuroscience
Pain Research
Sensory Physiology

Background:

Chronic pain conditions often involve altered cold temperature sensitivity.
Understanding the neurobiology of thermal sensitivity changes is crucial for developing effective pain therapies.
Current methods for measuring human thermal sensitivity can be inaccessible and costly, hindering research progress.

Observation:

An inexpensive assay using dry ice and a thermode was developed to measure cold pain thresholds.
During preliminary testing, one subject experienced prolonged epidermal postinflammatory hyperpigmentation lasting over 200 days.
This unique adverse event among a small cohort prompted a safety evaluation of the assay design.

Findings:

The developed assay provides a low-cost approach to assessing cold pain thresholds in humans.
A rare but significant adverse event (prolonged skin hyperpigmentation) was identified during assay development.
The occurrence of this side effect necessitates further investigation into the assay's safety profile.

Implications:

The findings highlight the need for rigorous safety assessments in the development of new sensory testing methods.
Further research is required to understand the mechanism behind the observed hyperpigmentation and mitigate risks.
Addressing safety concerns is critical for the potential clinical adoption of this affordable thermal sensitivity measurement technique.