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Updated: Feb 27, 2026

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
Minimal time spiking in various ChR2-controlled neuron models
Vincent Renault1, Michèle Thieullen2, Emmanuel Trélat3
1Laboratoire de Probabilités et Modèles Aléatoires, CNRS UMR 7599, Sorbonne Universités, UPMC Univ Paris 06, 75005, Paris, France. vincent.renault7@gmail.com.
Abstract:
We use conductance based neuron models, and the mathematical modeling of optogenetics to define controlled neuron models and we address the minimal time control of these affine systems for the first spike from equilibrium. We apply tools of geometric optimal control theory to study singular extremals, and we implement a direct method to compute optimal controls. When the system is too large to theoretically investigate the existence of singular optimal controls, we observe numerically the optimal bang-bang controls.

