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Immune disorders induced by exposure to pyrethroid insecticides.
Justyna Skolarczyk1, Joanna Pekar1, Barbara Nieradko-Iwanicka2
1Studenckie Koło Naukowe przy Katedrze i Zakładzie Higieny Uniwersytetu Medycznego w Lublinie.
Postepy Higieny I Medycyny Doswiadczalnej (Online)
|July 1, 2017
Summary
Pyrethroids, widely used insecticides, can suppress the immune system in humans and animals. Research shows they reduce immune cell function and increase susceptibility to infections and potentially cancer.
Area of Science:
- Toxicology
- Immunology
- Environmental Health
Background:
- Pyrethroids are third-generation insecticides with selective toxicity.
- They are less harmful to birds and mammals but toxic to fish and insects.
- Their neurotoxic mechanism involves voltage-sensitive sodium and chloride channels.
Purpose of the Study:
- To review current knowledge on pyrethroid effects on the immune system.
- To synthesize findings from recent scientific research.
Main Methods:
- Literature review of scientific studies on pyrethroids and immunity.
- Analysis of research detailing pyrethroid mechanisms and observed immune effects.
Main Results:
- Pyrethroids cause immune disorders, lowering immunity in humans and animals.
- Observed effects include inhibited leukocyte proliferation, reduced IgG, macrophages, IL-2, IL-8, IL-12p70, and IFN-γ.
- Potential effects include increased liver weight, bone marrow cellularity, thymus apoptosis, allergies, asthma, and cancer induction.
Conclusions:
- Pyrethroids possess immunosuppressive properties.
- These effects can impair host resistance to infections.
- Pyrethroid exposure may increase cancer risk, particularly in immunocompromised individuals.
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