Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal escape from dexamethasone suppression in agoraphobia with panic attacks.

W Coryell, R Noyes, J Clancy

    Psychiatry Research
    |August 1, 1985
    PubMed
    Summary

    Panic disorder and major depression are distinct conditions, despite both showing similar hypothalamic-pituitary-adrenal axis hyperactivity. Dexamethasone suppression tests (DSTs) did not differentiate between these disorders in patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Project SATURN- a real-world evidence data collaboration with existing European datasets in Osteogenesis Imperfecta to support future therapies.

    Orphanet journal of rare diseases·2024
    Same author

    Measuring the development of a medical professional identity through medical school.

    Medical teacher·2023
    Same author

    Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans.

    Cell death & disease·2022
    Same author

    Burden of Silicosis among stone crushing workers in India.

    Occupational medicine (Oxford, England)·2021
    Same author

    A comparison of standard two-dimensional ultrasound to three-dimensional volume sonography for routine second-trimester fetal imaging.

    Journal of perinatology : official journal of the California Perinatal Association·2017
    Same author

    The Hysterical personality.

    Postgraduate medicine·2016

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Clinical Psychology

    Background:

    • The hypothalamic-pituitary-adrenal (HPA) axis is implicated in both panic disorder and major depression.
    • Dexamethasone suppression tests (DSTs) have been used to assess HPA axis function in these conditions.
    • Previous research suggests potential overlap in DST abnormalities between agoraphobia with panic attacks and major depression.

    Purpose of the Study:

    • To investigate and compare the utility of DSTs in differentiating between agoraphobia with panic attacks and major depression.
    • To examine the relationship between HPA axis hyperactivity and these two distinct diagnostic groups.
    • To assess whether HPA axis dysfunction is a primary feature or a secondary epiphenomenon in panic disorder and depression.

    Main Methods:

    Related Experiment Videos

    • Patients meeting DSM-III criteria for agoraphobia with panic attacks underwent serial DSTs during treatment with alprazolam or placebo.
    • Outpatients with major depression received multiple DSTs as part of a desmethylimipramine efficacy study.
    • Comparison of DST nonsuppression rates between the two diagnostic groups and analysis of DST changes relative to clinical improvement.

    Main Results:

    • The likelihood of abnormal dexamethasone escape was comparable between patients with agoraphobia and major depression.
    • DST nonsuppression was slightly more prevalent in primary depression but not statistically significant compared to agoraphobia.
    • Changes in DST results correlated with clinical changes in agoraphobic patients during treatment.

    Conclusions:

    • Panic disorder and primary major depression are distinct psychiatric illnesses.
    • HPA axis hyperactivity appears to be an epiphenomenon, rather than a core differentiating feature, of both conditions.
    • DSTs are not sufficiently discriminative to distinguish between panic disorder and major depression.