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One-Dimensional Luminous Nanorods Featuring Tunable Persistent Luminescence for Autofluorescence-Free Biosensing
Jie Wang, Qinqin Ma, Wei Zheng1
1CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou, Fujian 350002, China.
ACS Nano
|July 1, 2017
Summary
Researchers developed tunable zinc germanium oxide nanorods (ZGO:Mn NRs) for biomedical imaging. These persistent luminescence nanoparticles (PLNPs) eliminate autofluorescence and show potential for clinical diagnostics.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Persistent luminescence nanoparticles (PLNPs) offer advantages in biomedicine by overcoming tissue autofluorescence.
- Controlled synthesis of PLNPs with tunable properties remains a challenge.
- Previous studies focused on quasi-spherical ZnGa2O4:Cr PLNPs, with limited exploration of other shapes and compositions.
Purpose of the Study:
- To report the direct synthesis of Zn2GeO4:Mn (ZGO:Mn) persistent luminescence nanorods (NRs).
- To investigate the tunability of ZGO:Mn NRs' length and luminescence properties.
- To demonstrate the application of ZGO:Mn NRs in biosensing for clinical sample analysis.
Main Methods:
- Direct synthesis of ZGO:Mn nanorods via a hydrothermal method.
- Tuning nanorod length and luminescence by adjusting the pH of the reaction system.
- Construction of aptamer-guided ZGO:Mn bioprobes for serum lysozyme detection.
Main Results:
- ZGO:Mn NRs were successfully synthesized with tunable length and strong persistent luminescence.
- Rapid synthesis achieved within 30 minutes of hydrothermal treatment.
- Aptamer-guided ZGO:Mn bioprobes effectively eliminated serum autofluorescence for accurate lysozyme quantification in cancer patient samples.
Conclusions:
- ZGO:Mn NRs offer tunable properties and effective autofluorescence elimination for biosensing.
- The developed bioprobes show significant potential for analyzing clinical samples and advancing biomolecular studies.
