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Updated: Feb 27, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects
Matthew P Murphy1, Dre Irizarry, Michael Lopez
1*Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division †Stanford Stem Cell Biology and Regenerative Medicine Institute, Stanford University, Stanford, CA.
Abstract:
Craniofacial surgery, since its inauguration, has been the culmination of collaborative efforts to solve complex congenital, dysplastic, oncological, and traumatic cranial bone defects. Now, 50 years on from the first craniofacial meeting, the collaborative efforts between surgeons, scientists, and bioengineers are further advancing craniofacial surgery with new discoveries in tissue regeneration. Recent advances in regenerative medicine and stem cell biology have transformed the authors' understanding of bone healing, the role of stem cells governing bone healing, and the effects of the niche environment and extracellular matrix on stem cell fate. This review aims at summarizing the advances within each of these fields.
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