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Rare Dual Lesion: Extraskeletal Osteosarcoma Developing Within a Simple Lipoma.

Jonathan Tresley¹, Ross Wodicka, Andrew Rosenberg

¹Advocate Health System, Chicago, IL. JTRadiology@gmail.com.

American Journal of Orthopedics (Belle Mead, N.J.)

|July 1, 2017

Summary

This is the first report of radiation-induced extraosseous osteosarcoma developing within a simple lipoma. Imaging and treatment outcomes are presented for this rare malignancy.

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Area of Science:

Oncology
Radiology
Pathology

Background:

Extraosseous osteosarcoma is a rare malignant bone tumor.
Simple lipomas are common benign soft tissue tumors.
The development of malignancy within a benign lesion is uncommon.

Observation:

A 72-year-old woman developed radiation-induced extraosseous osteosarcoma within a pre-existing simple lipoma.
The case involved detailed correlation of magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and plain radiography.
The patient underwent systemic therapy and wide surgical resection.

Findings:

The study presents a unique case of a rare malignancy arising within a common benign tumor.
Multimodality imaging findings were correlated to characterize the lesion.
The patient achieved disease-free status for 22 months post-treatment.

Implications:

This case highlights a rare but significant potential complication of radiation therapy.
Understanding the imaging characteristics is crucial for diagnosis.
Further research may elucidate the mechanisms of radiation-induced sarcomagenesis within lipomas.