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Developing and validating a new nomogram for diagnosing bladder outlet obstruction in women
Eskinder Solomon1, Habiba Yasmin1, Megan Duffy1
1University College London Hospitals NHS Trust, London, UK.
A new nomogram helps diagnose bladder outlet obstruction (BOO) in women using detrusor pressure (Pdet.Qmax) and maximum flow rate (Qmax). This tool accurately identifies obstruction, aiding in treatment assessment.
Area of Science:
- Urology
- Medical Imaging
- Diagnostic Tools
Background:
- Bladder outlet obstruction (BOO) in women is challenging to diagnose.
- Accurate assessment requires reliable diagnostic tools.
Purpose of the Study:
- To develop and validate a nomogram for assessing female BOO.
- To utilize concurrent Pdet.Qmax and Qmax measurements with radiographic evidence.
Main Methods:
- Retrospective analysis of video-urodynamics and clinical data from 535 women.
- Cluster analysis to define the obstruction axis (Pdet.Qmax = 2*Qmax).
- Development and validation of a nomogram using logistic regression.
Main Results:
- The derived criterion showed high sensitivity (0.94) and specificity (0.93).
- A nomogram and a female BOO index (BOOIf) were created for probability assessment.
- BOOIf formula: Pdet.Qmax - 2.2*Qmax.
Conclusions:
- The proposed female BOO nomogram (SG nomogram) offers high accuracy.
- This tool can stratify BOO severity and monitor treatment response.
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