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Updated: Feb 27, 2026
A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
modPhEA: model organism Phenotype Enrichment Analysis of eukaryotic gene sets
Meng-Pin Weng1, Ben-Yang Liao1
1Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
Motivation:
Genome-scale phenotypic data are available for many model organisms, yet existing tools to functionally interpret gene sets from these phenotypic data are largely based on mutagenesis-derived phenotypes observed in mouse or human.
Results:
Data from both mutagenesis and knockdown experiments are incorporated into modPhEA to allow users to perform enrichment analyses based on phenotypes observed in budding yeast (Saccharomyces cerevisiae), roundworm (Caenorhabditis elegans), fruit fly (Drosophila melanogaster), zebrafish (Danio rerio), mouse (Mus musculus) and humans (Homo sapiens). The phenotypes analysed can be customized to investigate complex traits and gene sets from any fully sequenced animal or fungal genome are also supported by modPhEA.
Availability And Implementation:
Freely available on the web at http://evol.nhri.org.tw/modPhEA/.
Contact:
liaoby@nhri.org.tw.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
