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[Acute beta blocker poisoning].

G Oltmanns, H Schwela, B Kulick

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |September 15, 1985
    PubMed
    Summary
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    Acute beta-blocker poisoning, particularly with talinolol and propranolol, can cause life-threatening symptoms like dysrhythmias and hypotension. Early and intensive therapy is crucial for survival in severe intoxication cases.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Cardiology

    Context:

    • Beta-blockers are widely prescribed cardiovascular medications.
    • Acute intoxication can occur from intentional or accidental overdose.
    • Understanding substance-specific toxicity is vital for clinical management.

    Purpose:

    • To analyze clinical presentations and outcomes of acute beta-blocker intoxications.
    • To compare the toxicity profiles of talinolol and propranolol.
    • To identify factors influencing prognosis and guide therapeutic strategies.

    Summary:

    • This study examined 34 cases of acute beta-blocker intoxication (16 talinolol, 18 propranolol).
    • Common symptoms included antiadrenergic effects, dysrhythmias, hypotension, and central-nervous symptoms, with loss of cardioselectivity at high doses.

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  • Lethality was associated with doses over 2g, delayed/insufficient therapy, and required intensive interventions like antidotes, pacemakers, and ICU care.

    • Impact:

    • Highlights the significant risks associated with high-dose beta-blocker ingestion.
    • Emphasizes the need for prompt and aggressive management in beta-blocker overdose.
    • Informs emergency medical protocols for treating severe beta-blocker toxicity.