Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional

R Bolli, W X Zhu, M L Myers

    The American Journal of Cardiology
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cyclosporin in cell therapy for cardiac regeneration.

    Journal of cardiovascular translational research·2014
    Same author

    Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2013
    Same author

    In-vitro translation of different mRNA-containing fractions of Chlamydomonas chloroplasts.

    Planta·2013
    Same author

    Mechanisms of stem cell effects: insights from MRI.

    Minerva cardioangiologica·2013
    Same author

    A stochastic analysis of tractor overturn costs on catfish farms.

    Journal of agricultural safety and health·2012
    Same author

    ROPS deficiency of gray-market tractors.

    Journal of agricultural safety and health·2012

    Struggling stunned myocardium (heart muscle) can significantly improve with beta-adrenergic stimulation, challenging the ATP depletion theory. This suggests inotropic therapy may safely reverse post-ischemic dysfunction in humans.

    Area of Science:

    • Cardiovascular Physiology
    • Myocardial Ischemia and Reperfusion

    Background:

    • Prolonged myocardial dysfunction after reversible ischemia, known as stunned myocardium, is often attributed to impaired ATP replenishment in myocytes.
    • This hypothesis suggests that inotropic stimulation should yield minimal contractile improvement or even worsen function in stunned myocardium.

    Purpose of the Study:

    • To investigate the contractile response of stunned myocardium to beta-adrenergic stimulation.
    • To determine if inotropic therapy can reverse post-ischemic dysfunction without adverse short-term effects.

    Main Methods:

    • Open-chest dogs underwent 15-minute left anterior descending coronary artery (LAD) occlusion followed by 4 hours of reperfusion.
    • Systolic wall thickening (an index of regional myocardial function) was measured using ultrasonic crystals.

    Related Experiment Videos

  • Isoproterenol was administered intravenously to treated dogs 3 hours after reperfusion.

    • Main Results:

    • Myocardial thickening fraction was severely depressed after reperfusion (2.6 +/- 3.4%) compared to baseline (20.8 +/- 3.0%).
    • Isoproterenol administration significantly increased thickening fraction to baseline levels (24.8 +/- 4.5%) without adverse effects.
    • Function returned to pre-treatment levels after isoproterenol discontinuation.

    Conclusions:

    • Reperfused, stunned myocardium demonstrates a robust response to beta-adrenergic stimulation.
    • These findings do not support the ATP depletion theory for post-ischemic dysfunction.
    • Inotropic therapy shows potential for effectively reversing human post-ischemic dysfunction without short-term harm.