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Published on: August 10, 2018
MicroRNA in glutamate receptor-dependent neurological diseases
Walid A Alsharafi1, Zhaohui Luo1, Xiaoyan Long1
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Abstract:
Glutamate-mediated excitotoxicity is the major neuropathological process contributing to numerous neurological diseases. Recently, emerging evidence indicates that microRNAs (miRNAs) play essential roles in the pathophysiology of a wide range of neurological diseases. Notably, there have been significant developments in understanding the biogenesis of miRNAs, their regulatory mechanisms, and their potential as effective biomarkers and therapies. In the present review, we summarize the recent literature that highlights the versatile roles played by miRNAs in glutamate receptor (GluR)-dependent neurological diseases. Based on the reported studies to date, modulation of miRNAs could emerge as a promising therapeutic target for a variety of neurological diseases that were discussed in this review.
Insights
MicroRNAs (miRNAs) are crucial in neurological diseases caused by glutamate excitotoxicity. Targeting these miRNAs offers a promising therapeutic strategy for various brain disorders.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Glutamate excitotoxicity is a key factor in many neurological diseases.
- MicroRNAs (miRNAs) are increasingly recognized for their significant roles in neurological disease pathophysiology.
- Understanding miRNA biogenesis and regulation is vital for developing new treatments.
Purpose of the Study:
- To review the current literature on the roles of miRNAs in glutamate receptor (GluR)-dependent neurological diseases.
- To highlight the potential of miRNAs as biomarkers and therapeutic agents.
- To discuss the implications of miRNA modulation for treating neurological disorders.
Main Methods:
- Literature review of recent studies on miRNAs and neurological diseases.
- Analysis of research on miRNA biogenesis and regulatory mechanisms.
- Synthesis of findings related to miRNA involvement in glutamate receptor-mediated excitotoxicity.
Main Results:
- miRNAs play versatile roles in the pathophysiology of neurological diseases.
- Evidence supports the potential of miRNAs as biomarkers for neurological conditions.
- Modulation of miRNAs shows promise as a therapeutic approach.
Conclusions:
- miRNAs are critical players in glutamate receptor-dependent neurological diseases.
- Targeting miRNAs presents a promising therapeutic avenue for various neurological disorders.
- Further research into miRNA mechanisms can lead to novel treatments.
