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Published on: March 4, 2022
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Translational science in chronic kidney disease
Maria Dolores Sanchez-Niño1, Ana B Sanz1, Adrian M Ramos1
1IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid; Fundacion Renal Iñigo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain.
Clinical Science (London, England : 1979)
|July 2, 2017
Summary
Chronic kidney disease (CKD) is a growing global health threat. Addressing translational research gaps is crucial to improve patient outcomes and implement existing advances effectively.
Area of Science:
- Nephrology
- Translational Research
- Public Health
Background:
- Chronic kidney disease (CKD) definition by KDIGO aids characterization but reveals a worrisome translational gap.
- CKD is a rapidly increasing cause of mortality globally.
- Sequential roadblocks in translational research (T1, T2, T3) hinder progress from basic science to clinical practice and implementation.
Purpose of the Study:
- To review recent advances and novel concepts in nephrology.
- To identify strategies for improving CKD patient outcomes and global implementation of care.
- To address the challenges in translational research for CKD.
Main Methods:
- Review of recent scientific literature and clinical advances in nephrology.
- Analysis of translational research (T1, T2, T3) bottlenecks.
- Exploration of updated CKD concepts and diagnostic/therapeutic strategies.
Main Results:
- Proposed updating the CKD concept to focus on early detection, risk stratification, and care.
- Highlighted advances in characterizing etiological factors, including genetics, liquid biopsy, and SGLT2 inhibitors for diabetic kidney disease (DKD).
- Emphasized viewing CKD as a network disease and optimizing knowledge implementation.
Conclusions:
- Addressing translational research gaps is essential to combat rising CKD mortality.
- Novel approaches in CKD concept, etiology, and treatment hold promise for improved patient outcomes.
- Optimizing the implementation of existing and emerging knowledge is critical for global CKD management.
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