Short-term effects of ambient air pollution and childhood lower respiratory diseases

The association between air pollution and childhood respiratory disease is inconsistent. In the present study, we investigated a short-term effect of ambient air pollutants and daily childhood lower respiratory diseases (CLRD). Daily air pollutants, weather data, and CLRD data were collected from January 2014 to April 2015 (452 days) in Nanjing, China. Time-series regression and generalized additive models were used to assess the effects of air pollutants (PM₁₀, PM_2.5, NO₂, SO₂, O₃, and CO) on CLRD. We observed that an interquartile range (IQR) increase in concentrations of PM₁₀, NO₂, and SO₂ significantly increased the daily CLRD with 6 days cumulative effects (difference of estimates: 2.8%, 95% CI: 0.6-5.0%; 4.1%, 1.2-7.0%; 5.6%, 2.6-8.6%, respectively). However, no significant association was found in IQR concentrations of PM_2.5, O₃, and CO. Specifically, elevated PM₁₀, PM_2.5, NO₂, and SO₂ significantly increased the numbers of CLRD in cool season (3.6%, 1.5-5.7%; 2.4%, 0.3-4.5%; 4.9%, 2.9-7.0%; 6.3%, 3.7-9.0%, respectively). Additionally, the effect estimates of PM₁₀, NO₂, and SO₂ in female and age >27 months were more pronounced than in male and age ≤27 months. This study suggested that short-term exposure to ambient PM₁₀, NO₂, and SO₂ were associated with the increased CLRD numbers.