Coagulation abnormalities in children with Celiac disease

Area of Science:

• Pediatric Gastroenterology
• Hematology
• Coagulation Disorders

Background:

• Celiac disease is an autoimmune disorder triggered by gluten ingestion.
• Coagulation abnormalities can occur in various gastrointestinal conditions.
• The relationship between Celiac disease severity and coagulation status in children requires further elucidation.

Purpose of the Study:

• To investigate the prevalence of coagulation abnormalities in children with Celiac disease at diagnosis.
• To assess the association between coagulation status and the histological grade of Celiac disease (Marsh Grade) in pediatric patients.

Main Methods:

• Prospective analysis of 111 children diagnosed with Celiac disease.
• Evaluation of coagulation parameters, including prothrombin time.
• Correlation of coagulation findings with duodenal biopsy histology (Marsh Grade).

Main Results:

• 27% of children with Celiac disease presented with a deranged prothrombin time at diagnosis.
• A significant trend showed an increasing proportion of coagulopathy with the progression of Marsh Grade.
• Higher histological severity correlated with a greater likelihood of coagulation abnormalities.

Conclusions:

• Coagulation abnormalities are a notable finding in pediatric Celiac disease at diagnosis.
• The severity of Celiac disease, as indicated by Marsh Grade, is associated with the presence and extent of coagulopathy.
• These findings highlight the importance of assessing coagulation in children with Celiac disease, particularly those with more advanced histological findings.