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Coagulation abnormalities, including prolonged prothrombin time, are common in children diagnosed with Celiac disease. These blood clotting issues worsen with increasing Marsh Grade severity on duodenal biopsy.

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Area of Science:

  • Pediatric Gastroenterology
  • Hematology
  • Coagulation Disorders

Background:

  • Celiac disease is an autoimmune disorder triggered by gluten ingestion.
  • Coagulation abnormalities can occur in various gastrointestinal conditions.
  • The relationship between Celiac disease severity and coagulation status in children requires further elucidation.

Purpose of the Study:

  • To investigate the prevalence of coagulation abnormalities in children with Celiac disease at diagnosis.
  • To assess the association between coagulation status and the histological grade of Celiac disease (Marsh Grade) in pediatric patients.

Main Methods:

  • Prospective analysis of 111 children diagnosed with Celiac disease.
  • Evaluation of coagulation parameters, including prothrombin time.
  • Correlation of coagulation findings with duodenal biopsy histology (Marsh Grade).

Main Results:

  • 27% of children with Celiac disease presented with a deranged prothrombin time at diagnosis.
  • A significant trend showed an increasing proportion of coagulopathy with the progression of Marsh Grade.
  • Higher histological severity correlated with a greater likelihood of coagulation abnormalities.

Conclusions:

  • Coagulation abnormalities are a notable finding in pediatric Celiac disease at diagnosis.
  • The severity of Celiac disease, as indicated by Marsh Grade, is associated with the presence and extent of coagulopathy.
  • These findings highlight the importance of assessing coagulation in children with Celiac disease, particularly those with more advanced histological findings.