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Genetic variants and risk of asthma in an American Indian population

Lyle G Best1, Crystal Azure2, Alexandre Segarra2

  • 1Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota; Science Department, Turtle Mountain Community College, Belcourt, North Dakota; School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|July 3, 2017
PubMed

Insights

Genetic variants linked to asthma in other populations are also associated with the condition in American Indian children. Obesity may also increase asthma risk in this group.

Area of Science:

  • Genetics
  • Pediatrics
  • Epidemiology

Background:

  • Asthma is a complex, multifactorial disease with a known genetic component.
  • Previous studies have identified specific genetic variants associated with asthma risk in various populations.

Purpose of the Study:

  • To investigate whether known asthma-associated genetic variants increase asthma risk in American Indian children.
  • To explore the relationship between genetic factors, obesity, and asthma in this specific demographic.

Main Methods:

  • Case-control study utilizing electronic medical records from an Indian Health Service facility.
  • Genotyping of 10 single-nucleotide polymorphisms (SNPs) at 6 genetic loci in 108 children with asthma and 216 matched controls.
  • Statistical analysis using chi-squared tests and logistic regression, including adjustments for age, body mass index, and atopy.

Main Results:

  • A significant association was found between a variant at 5q22.1 (rs10056340) and asthma risk (P < .001).
  • Variants at 5q22.1 and 17q21 (rs9303277) were independently associated with asthma (P < .05).
  • Obesity was also identified as a risk factor for asthma in American Indian children.

Conclusions:

  • Genetic variants commonly associated with asthma in other populations are relevant to American Indian children.
  • These findings highlight the importance of genetic predisposition and environmental factors like obesity in childhood asthma within this population.
Abstract

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