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Updated: Feb 27, 2026
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
Correlation Between Thrombospondin-1 Expression in Non-cancer Tissue and Gastric Carcinogenesis
Hideya Kashihara1, Mitsuo Shimada2, Kozo Yoshikawa2
1Department of Surgery, Institute of Health Biosciences, University of Tokushima, Tokushima, Japan kashihara.hideya@tokushima-u.ac.jp.
Background/Aim:
Thrombospondin-1 (TSP1) is correlated with carcinogenesis occurring in cases of intestinal inflammation. The aim of this study was to clarify the role of TSP1 in gastric carcinogenesis.
Materials And Methods:
A total of 39 patients with gastric cancer who had undergone gastrectomy were enrolled. The expression of TSP1 mRNA in non-cancer tissues was determined. Furthermore, the expression of CD36, STAT3 and TGFβR2 mRNA in non-cancer tissues in two expression groups, the TSP1 high- and low-expression groups, were examined.
Results:
The expression of TSP1 was high in the mucosal-atrophy group and tended to be high in the Helicobacter pylori (H. pylori) (+) and multiple cancer groups. The levels of CD36, STAT3 and TGFβR2 mRNA were significantly higher in the TSP1-high group. TSP1 signaling pathway was induced in multiple cancer or atrophy (+) or H. pylori (+) compared to cases with single cancer, atrophy (-) and H. pylori (-). Expression of proteins involved in the TSP1 signaling pathway in non-cancer tissues with multiple gastric cancers were higher than that with single gastric cancer.
Conclusion:
Expression of TSP1 in non-cancer tissue correlated with gastric carcinogenesis.
