Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

5.1K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.1K
Clinical Trials01:16

Clinical Trials

10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

503
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
503
Hazard Ratio01:12

Hazard Ratio

661
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
661
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.7K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.7K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

192
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
192

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: A systematic review and meta-analysis of adolescent nutrition in Ethiopia: Transforming adolescent lives through nutrition (TALENT) initiative.

PloS one·2026
Same author

Clinical and echocardiographic characteristics of patients who developed adverse events following Benzathine penicillin G injection for secondary prophylaxis of rheumatic heart disease: a cross-sectional study from three university hospitals in Ethiopia.

Cardiovascular journal of Africa·2026
Same author

COP27 Climate Change Conference: urgent action needed for Africa and the world.

Public health challenges·2025
Same author

COP27 Climate Change Conference: Urgent Action Needed for Africa and the World: Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change.

Schizophrenia bulletin open·2024
Same author

COP27 Climate Change Conference: Urgent Action Needed for Africa and the world.

Nigerian medical journal : journal of the Nigeria Medical Association·2024
Same author

Mortality and Morbidity in Adults With Rheumatic Heart Disease.

JAMA·2024
Same journal

The Prevalence of Hospitalized Cases of Necrotizing Fasciitis: Anatomical Distribution, Amputations, and In-Hospital Mortality, 2019-2024.

Deutsches Arzteblatt international·2026
Same journal

Subclinical Atrial Fibrillation: Detection, Stroke Risk, and Treatment.

Deutsches Arzteblatt international·2026
Same journal

Fewer Premature Births After Assisted Reproduction.

Deutsches Arzteblatt international·2026
Same journal

Femoral Artery Pseudoaneurysm Due to Stent Fracture in PAOD.

Deutsches Arzteblatt international·2026
Same journal

Pain-Adapted Full Weight-bearing After Ankle Fracture Surgery: A Multicenter, Pragmatic, Single-armed Prospective Study.

Deutsches Arzteblatt international·2026
Same journal

Popliteal Artery Entrapment Syndrome.

Deutsches Arzteblatt international·2026
See all related articles

Related Experiment Video

Updated: Feb 27, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Data Sharing Statements for Clinical Trials

Darren B Taichman1, Peush Sahni, Anja Pinborg

  • 1ICMJE, Executive Deputy Editor, Annals of Internal Medicine, Representative and Past President, World Association of Medical Editors ( WAME); Scientific Editor-in-Chief, Ugeskrift for Læger (Danish Medical Journal); Chief Editor, PLOS Medicine; Editor-in-Chief, Annals of Internal Medicine; Deputy Editor, The Lancet; Editor-in-Chief, Journal of Korean Medical Science; Editor-in-Chief, Ethiopian Journal of Health Sciences; Editor, Bulletin of the World Health Organization, Coordinator, WHO Press; F.R.C.P., Editor-in-Chief, The BMJ (British Medical Journal); F.R.A.C.S., Editor-in-Chief, New Zealand Medical Journal; Editor, Revsita Médica de Chile (Medical Journal of Chile); Editor-in-Chief, New England Journal of Medicine; Editor-in-Chief, JAMA (Journal of the American Medical Association) & JAMA Network; Chief Scientific Editor, Deutsches Ärzteblatt (German Medical Journal) & Deutsches Ärzteblatt International; Representative and Associate Director for Library Operations, National Library of Medicine.

Deutsches Arzteblatt International
|July 4, 2017
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

5.8K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Related Experiment Videos

Last Updated: Feb 27, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K
Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

5.8K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K