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Updated: Feb 27, 2026

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
Published on: October 19, 2021
Mitochondrial control of immunity: beyond ATP
Manan M Mehta1, Samuel E Weinberg1, Navdeep S Chandel1
1Department of Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Avenue, M-334, Chicago, Illinois 60611, USA.
Abstract:
Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.
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