Related Experiment Video
Updated: Feb 27, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
3.6K
Redefining lupus nephritis: clinical implications of pathophysiologic subtypes
Feng Yu1,2, Mark Haas3, Richard Glassock4
1Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, P. R. China.
Nature Reviews. Nephrology
|July 4, 2017
Summary
Systemic lupus erythematosus (SLE) causes lupus nephritis, a major cause of death. Understanding its complex causes is key to better treatment, as current classifications don't fully reflect disease pathways.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Systemic lupus erythematosus (SLE) presents with diverse clinical and immunologic features.
- Lupus nephritis is the most frequent cause of morbidity and mortality in SLE patients.
- Nephritis development involves aberrant apoptosis, autoantibody production, immune complex deposition, and complement activation.
Purpose of the Study:
- To discuss the heterogeneous mechanisms in lupus nephritis pathogenesis.
- To explore how understanding disease mechanisms can guide therapeutic strategies.
- To highlight limitations of the current ISN/RPS classification system.
Main Methods:
- Review of pathogenic pathways in lupus nephritis.
- Analysis of the 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification system.
- Discussion of additional pathological lesions and their clinical relevance.
Main Results:
- The ISN/RPS classification, while useful, doesn't fully capture underlying disease pathophysiology.
- Additional lesions like glomerular crescents, podocyte injury, tubulointerstitial, and vascular injury are important.
- Improved understanding of lupus nephritis pathogenesis is crucial for effective treatment.
Conclusions:
- Current lupus nephritis classification needs refinement to better align with disease mechanisms.
- Therapeutic strategies should be guided by a deeper understanding of underlying pathogenesis.
- Further research into lupus nephritis mechanisms promises improved patient outcomes.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
748
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
748
01:29Acute Kidney Injury II: Pathophysiology
1.3K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.3K
01:26Nephrotic Syndrome II : Assessment and Medical Management
279
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
279
01:24Nephrotic Syndrome III : Nursing Management
398
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
398
01:10Nephrons
7.7K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
7.7K
01:25Chronic Kidney Disease I: Introduction
863
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
863