Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

441
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
441
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

660
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
660

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering human peritoneum in vitro: A novel microfluidic platform for modeling peritoneal physiology and pathophysiology.

Bioengineering & translational medicine·2026
Same author

Deep-sequencing-guided library screening and profiling of AAV capsids in the primate retina.

Molecular therapy. Advances·2026
Same author

Lymphoid-Tissue-on-Chip Recapitulates Human Antibody Responses In Vitro.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Reconstructing tumor tissues in 3D: From organoids to bioengineered niches.

Cell stem cell·2026
Same author

Navigating ADME profiling challenges in microphysiological systems: Evaluation of a liver-chip model for clearance prediction.

Journal of pharmaceutical sciences·2026
Same author

Listeria-infected macrophages promote biomechanical alterations in endothelial cell monolayers for transmigration.

Cell reports·2026

Related Experiment Video

Updated: Feb 27, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

27.6K

Integration concepts for multi-organ chips: how to maintain flexibility?!

Julia Rogal1, Christopher Probst1, Peter Loskill1

  • 1Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstrasse 12, 70569 Stuttgart, Germany.

Future Science OA
|July 4, 2017
PubMed
Summary

Multi-organ platforms integrate multiple organ tissues into microfluidic systems, creating advanced in vitro models. Flexible

Keywords:
drug developmentflexible multi-organ toolboxmicrofluidicsmulti-organ chiporgans-on-a-chippersonalized medicine

More Related Videos

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

29.8K
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

15.0K

Related Experiment Videos

Last Updated: Feb 27, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

27.6K
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

29.8K
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

15.0K

Area of Science:

  • Biotechnology and Bioengineering
  • Translational Medicine
  • Drug Discovery and Toxicology

Background:

  • Multi-organ platforms offer significant potential to revolutionize drug development, toxicological screening, personalized medicine, and disease modeling.
  • Integrating multiple organ tissues into microfluidic systems merges the benefits of human cell lines with the complex physiology of animal models.
  • This integration facilitates the creation of more in vivo-like in vitro models for enhanced research applications.

Purpose of the Study:

  • To review and elucidate the concept of flexible, 'mix-and-match' multi-organ platform toolboxes.
  • To discuss the advantages of flexible interconnection systems compared to static and semi-static platforms.
  • To identify and address the remaining challenges in the development and application of these advanced in vitro models.

Main Methods:

  • Categorization of existing multi-organ platform designs into static, semi-static, and flexible systems.
  • Focus on the flexible interconnection of single-organ platforms to create application-specific multi-organ systems.
  • Conceptual analysis and discussion of the 'mix-and-match' toolbox approach.

Main Results:

  • Flexible interconnection of single-organ platforms represents a highly promising approach for multi-organ systems.
  • This flexible approach offers numerous advantages over traditional static and semi-static platform designs.
  • Key challenges associated with flexible multi-organ platforms have been identified and discussed.

Conclusions:

  • Flexible multi-organ platforms, particularly those utilizing a 'mix-and-match' toolbox strategy, are poised to significantly advance in vitro research.
  • These systems provide a more physiologically relevant alternative to current models, accelerating drug development and personalized medicine.
  • Addressing identified challenges will be crucial for the widespread adoption and success of these innovative platforms.