Related Experiment Video
Updated: Feb 27, 2026
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Increased Levels of Serum Interleukin-17 in Patients with Hashimoto's Thyroiditis
Fatemeh Esfahanian1,2, Roghayeh Ghelich2, Hoda Rashidian1
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background:
CD4+ T-cells play important roles in the pathogenesis of Hashimoto's thyroiditis (HT). However, there is limited data about characteristics and function of the newly interleukin (IL)-17-producing T-helper cells in this common autoimmune thyroid disorder.
Aim:
The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT.
Materials And Methods:
Cytokine concentrations were measured in 48 patients with overt (n = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay.
Results:
The serum levels of IL-17 were significantly higher in patients than controls (P = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls.
Conclusion:
These results suggest that IL-17 could play some role in the pathogenesis of HT.
Related Concept Videos
01:24T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:20Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...