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Double versus single thrombophilias during pregnancy.

Rachel Carroll1, Andrei Rebarber2, Whitney Booker1

  • 1a The Department of Obstetrics, Gynecology, and Reproductive Science , Icahn School of Medicine at Mount Sinai , New York , USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 4, 2017
PubMed
Summary

Women with double thrombophilias (two inherited clotting disorders) did not experience more obstetric complications than those with single thrombophilias when treated with anticoagulation.

Keywords:
Adverse pregnancy outcomesanticoagulationdouble thrombophiliathrombophilia

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Genetics

Background:

  • Inherited thrombophilias increase the risk of blood clots.
  • The impact of having two thrombophilias on pregnancy outcomes is not well-established.

Purpose of the Study:

  • To compare obstetric complication rates in women with double thrombophilias versus single thrombophilias.
  • To evaluate the safety of anticoagulation treatment in these patient groups.

Main Methods:

  • Retrospective cohort study (2005-2013) of patients with inherited thrombophilias treated with anticoagulation.
  • Identified double thrombophilias (two conditions or homozygous mutations) and single thrombophilias.
  • Compared demographic and obstetric outcome data between groups.

Main Results:

  • Eighteen patients with double thrombophilias were identified.
  • No significant demographic differences were observed between single and double thrombophilia groups.
  • Obstetric outcomes were similar between women with single and double thrombophilias.

Conclusions:

  • Double thrombophilias do not appear to increase obstetric complication risk compared to single thrombophilias in anticoagulated patients.
  • Anticoagulation appears effective in managing risks associated with both single and double thrombophilias during pregnancy.