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Related Experiment Video

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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
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Fast, precise, and accurate myocardial T1 mapping using a radial MOLLI sequence with FLASH readout.

B Marty1,2, B Coppa1,2, P G Carlier1,2

  • 1Institute of Myology, NMR Laboratory, Paris, France.

Magnetic Resonance in Medicine
|July 4, 2017
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Summary

A new radial sequence (raMOLLI) significantly speeds up cardiac T1 mapping to five heartbeats, offering comparable accuracy to conventional methods for myocardial tissue characterization.

Keywords:
MOLLImyocardial T1 mappingradialtissue characterization

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Area of Science:

  • Cardiovascular magnetic resonance imaging
  • Medical imaging techniques
  • Myocardial tissue characterization

Background:

  • Quantitative cardiac MRI, particularly T1 mapping, is crucial for assessing myocardial tissue.
  • Conventional modified Look-Locker inversion recovery sequences have limitations in acquisition speed.

Purpose of the Study:

  • To demonstrate the value of a radial variant of the conventional modified Look-Locker inversion recovery sequence (raMOLLI).
  • To evaluate the raMOLLI sequence for ultrafast acquisition of myocardial T1 maps.

Main Methods:

  • Utilized a radial acquisition scheme (raMOLLI) with radial echo trains.
  • Employed view sharing and compressed sensing for image reconstruction.
  • Applied dictionary fitting to estimate T1 values from the T1 relaxation recovery curve.
  • Validated the sequence on phantoms, healthy subjects, and a patient with dilated cardiomyopathy.

Main Results:

  • raMOLLI significantly decreased myocardial T1 map acquisition time to five heartbeats.
  • Achieved higher accuracy and comparable precision in T1 estimation versus conventional sequences.
  • The FLASH readout showed better robustness to B0 inhomogeneities than TrueFISP, making it preferable for in vivo use.

Conclusions:

  • The raMOLLI sequence is a strong candidate for ultrafast myocardial T1 map acquisition.
  • This advancement facilitates more efficient cardiac MRI examinations.