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Factors related to retinal haemorrhage in infants born at high risk
Qinglan Pu1, Ping Li1, Huiqin Jiang1
1Department of Ophthalmology, Jiaxing Maternal and Child health care Hospital, Jiaxing, Zhejiang, China.
Insights
Retinal haemorrhage (RH) affects 18% of high-risk infants. Delivery mode and neonatal asphyxia are identified as significant risk factors for developing RH in these vulnerable newborns.
Area of Science:
- Ophthalmology
- Neonatology
- Perinatology
Background:
- Retinal haemorrhage (RH) is a known complication in newborns.
- Identifying risk factors is crucial for prevention and management in high-risk infants.
Purpose of the Study:
- To determine the incidence of retinal haemorrhage (RH) in high-risk infants.
- To identify specific risk factors associated with RH development in this population.
Main Methods:
- A cohort of 3123 high-risk infants (due to high-risk pregnancy and/or neonatal asphyxia) were studied.
- Fundus examinations were conducted using a wide-angle imaging system (RetCam III).
- Maternal, obstetric, and neonatal parameters were compared between infants with and without RH.
Main Results:
- The incidence of RH was 18% (550/3123 infants).
- RH was graded I (39%), II (24%), and III (37%).
- Delivery mode and neonatal asphyxia were identified as significant risk factors for RH.
Conclusions:
- The incidence of RH in high-risk infants is 18%.
- Delivery mode and neonatal asphyxia are major risk factors for RH.
- Early identification and intervention strategies targeting these factors are warranted.
Purpose:
This study aims to determine risk factors for retinal haemorrhage (RH) in high-risk infants.
Methods:
A total of 3123 cases with high-risk pregnancy and/or neonatal asphyxia 72 hr after delivery were enrolled into this study. Fundus examinations were performed on newborns utilizing a wide-angle imaging system (RetCam III). Retinal haemorrhage (RH) was classified into three grades. Maternal, obstetric and neonatal parameters from high-risk infants with RH were compared with parameters from infants without RH.
Results:
Retinal haemorrhage (RH) was found in 550 (18%) of 3123 high-risk infants. Retinal haemorrhage (RH) was classified as grade I (39%), grade II (24%) and grade III (37%). Monocular RH occurred in 37% of cases, while the remaining cases were binocular. Moreover, six cases had vitreous haemorrhage. The following parameters correlated (p < 0.05) with RH in this study: delivery mode (χ2 = 469), gestational age (χ2 = 35), birth weight (χ2 = 18), asphyxia (χ2 = 73), scalp hematoma (χ2 = 55), maternal age (χ2 = 8.9), precipitate labour (χ2 = 120) and delivery times (χ2 = 6.1). Logistic regression analysis indicated that delivery mode and asphyxia were risk factors for RH in high-risk infants, with odds ratios of 0.827 and 2.5, respectively. Gender, intracranial haemorrhage and foetal distress were not correlated with RH in high-risk infants.
Conclusion:
The incidence of RH in high-risk infants was 18%, and delivery mode, and neonatal asphyxia were major risk factors for RH in high-risk infants.
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