Related Experiment Video
Updated: Aug 16, 2026

A System to Create Stable Nanoparticle Aerosols from Nanopowders
Published on: July 26, 2016
Relationship between particle packing and the physical stability of powder mixes
Abstract:
The segregation tendency of powder mixes containing sugar-based direct compression tableting excipients with comparable particle size distributions and flow properties was studied under different vibration conditions. It was found that Tabfine and fine-particle pyridoxine hydrochloride mixes were virtually segregation-free, whereas segregation occurred in each of the other powder mixes containing Fast-flo, Dipac and Nu-tab. The segregation tendency of a specific powder mix following vibration was considered to be influenced by the packing of excipient particles in the powder bed. In general, the more densely packed the particles under given vibration conditions, the lower the segregation tendency. This was considered to be due to the tightly packed powder bed restricting individual particle movement and thereby reducing particle or ordered unit rearrangement.
More Related Videos
Related Concept Videos
Nuclear Stability
To hold positively charged protons together in the...
Intermolecular Forces and Physical Properties
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Equilibrium Conditions for a Particle
To understand the concept of equilibrium, let us first consider the forces acting on an object. When different forces act on an object, they can...
The Colloidal State
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

