Kinetics of D-alpha-tocopherol in a water soluble base in man

The kinetics of D-alpha-tocopherol (vitamin E) were investigated in 10 healthy, adult volunteers following a single dose of 500 iu D-alpha-tocopherol. Plasma concentration/time curves fitted using a one compartment open model, showed a rise to 12 +/- 1.9 mumol litre-1 above endogenous values over 8-9 h and then a tailing away to 7 +/- 1.1 mumol litre-1 after 24 h.