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Uzoagu A Okonkwo1,2, Luisa A DiPietro3

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Diabetes Mellitus Type II (DM2) impairs skin wound healing by affecting all stages, particularly angiogenesis. This review examines diabetic wound healing aberrations and potential therapeutics.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Vascular Biology

Background:

  • Diabetes Mellitus Type II (DM2) is a global health issue with severe complications.
  • Diabetic complications include poor wound healing, chronic ulceration, and limb amputation.
  • DM2 negatively impacts all phases of skin wound healing.

Purpose of the Study:

  • To review the aberrations in diabetic wound healing, focusing on angiogenesis.
  • To examine the proliferative, remodeling, and maturation phases of wound angiogenesis in diabetes.
  • To consider promising therapeutics for improving diabetic wound healing.

Main Methods:

  • This is a review article.
  • Literature search on diabetic wound healing and angiogenesis.
  • Analysis of described aberrations in wound healing phases.

Main Results:

  • Diabetes adversely affects all stages of skin wound healing.
  • Poor vascular networks are closely linked to the progression of non-healing diabetic wounds.
  • Aberrations in proliferative, remodeling, and maturation phases of angiogenesis are key.

Conclusions:

  • Diabetic wound healing is significantly impaired due to multi-faceted etiologies.
  • Aberrant angiogenesis is a critical factor in non-healing diabetic wounds.
  • Further research into therapeutics is needed to improve outcomes.