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Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
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Structural and functional ventilatory impairment in infants with severe bronchopulmonary dysplasia

Esther van Mastrigt1,2, Ellaha Kakar3, Pierluigi Ciet4

  • 1Division of Pediatric Respiratory Medicine, Department of Pediatrics, Erasmus MC-Sophia, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Pediatric Pulmonology
|July 4, 2017
PubMed

Insights

Preterm infants with severe bronchopulmonary dysplasia (BPD) often have lung structure abnormalities and impaired breathing. Early infant growth is linked to better lung development and fewer breathing issues.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Medical Imaging

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication in premature infants.
  • Severe BPD impacts lung structure and ventilatory function.
  • Early postnatal growth may influence BPD outcomes.

Purpose of the Study:

  • To characterize lung structure and ventilatory function in preterm infants with severe BPD.
  • To investigate the relationship between early postnatal growth and BPD-related outcomes.

Main Methods:

  • Included preterm infants (≤32 weeks GA) with severe BPD.
  • Assessed lung structure via chest CT (PRAGMA-BPD score).
  • Evaluated ventilatory function using polysomnography (PSG) at 6 months corrected age.
  • Tracked postnatal growth (birth, 2, and 6 months corrected age).

Main Results:

  • 95.5% of infants showed lung architectural distortion; 74% had an oxygen desaturation index (ODI) >5.
  • Increased gestational age (GA) correlated with better lung volumes and lower ODI.
  • Higher weight at 6 months and improved weight gain between 2-6 months were linked to better lung volumes and less severe desaturations.

Conclusions:

  • Preterm infants with severe BPD exhibit early structural lung deficits and impaired ventilatory function.
  • Birth characteristics and postnatal growth significantly influence BPD outcomes.
  • Optimizing infant growth may mitigate respiratory complications in severe BPD.
Abstract

Keywords:
chest CT scanchronic lung diseasefollow upgrowthpolysomnography

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