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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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mirMachine: A One-Stop Shop for Plant miRNA Annotation
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miRNAs in vascular integrity.

Yong Cao1, Pei-Ying Zhang2

  • 1Department of Cardiology, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.

Experimental and Therapeutic Medicine
|July 5, 2017
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate endothelial cell (EC) function, impacting vascular integrity and angiogenesis. Targeting these miRNAs offers potential therapies for cardiovascular diseases and cancer.

Keywords:
cardiovascular diseasesendothelial cell regulationmiRNAs

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Area of Science:

  • Vascular Biology and Molecular Medicine
  • Genetics and Epigenetics

Background:

  • Endothelial cells (ECs) are crucial for vascular integrity, angiogenesis, and wound repair.
  • MicroRNAs (miRNAs) play significant roles in regulating EC function and proliferation.
  • Dysregulation of ECs is implicated in various diseases, including cardiovascular conditions and cancer.

Purpose of the Study:

  • To review the regulatory roles of specific miRNAs in endothelial cell biology.
  • To highlight the therapeutic potential of miRNAs in cardiovascular diseases and cancer-related angiogenesis.

Main Methods:

  • Literature review of studies investigating miRNA function in endothelial cells.
  • Analysis of experimental data on miRNA knockdown effects on EC regulators.
  • Synthesis of findings related to ECs, miRNAs, and angiogenesis.

Main Results:

  • Several miRNAs have been identified to regulate EC function, proliferation, and growth.
  • miRNA knockdown alters key angiogenesis regulators like VEGFR2 and eNOS.
  • miRNAs influence tubule formation capacity in ECs.

Conclusions:

  • miRNAs are critical regulators of endothelial cell biology and angiogenesis.
  • Targeting specific miRNAs presents a promising therapeutic strategy for ischemic diseases and cancer.
  • Further research into miRNA-EC interactions is vital for developing novel treatments.