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Related Experiment Video

Updated: Feb 27, 2026

Measuring Lactase Enzymatic Activity in the Teaching Lab

Measuring Lactase Enzymatic Activity in the Teaching Lab

Published on: August 6, 2018

Lactase non-persistent genotype distribution in Italy.

Cristina Zadro¹, Savina Dipresa², Giovanni Zorzetti²

¹g&life SpA, Trieste, Italy - cristina.zadro@glifecompany.com.

Minerva Gastroenterologica E Dietologica

|July 5, 2017

Summary

Lactase non-persistence, a common cause of lactose malabsorption, shows a 62.3% prevalence in the Italian population. This study found no North-South gradient for adult hypolactasia across Italy.

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Last Updated: Feb 27, 2026

Measuring Lactase Enzymatic Activity in the Teaching Lab

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Published on: August 6, 2018

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Genetics
Human Physiology
Population Studies

Background:

Adult-type hypolactasia is a common lactose malabsorption condition.
European populations show a North-South gradient for this trait.
Lactase gene (LCT) genotyping is a diagnostic marker for hypolactasia.

Purpose of the Study:

Determine the prevalence of the lactase non-persistent CC-genotype in Italy.
Investigate the distribution of adult-type hypolactasia across Italian macro-regions.

Main Methods:

Genotyped 1312 adult Italians for the LCT-13910 C>T polymorphism.
Utilized KASPar chemistry for genotyping.

Main Results:

The overall frequency of the lactase non-persistence genotype (CC) was 62.3%.
Regional frequencies were 58.6% (North), 74.1% (Center), and 67.1% (South).
The observed prevalence exceeded previously reported values for Italy.

Conclusions:

This is the first large-scale analysis of LCT-13910 CC genotype distribution in Italy.
Data do not support a North-South gradient for adult hypolactasia in the Italian population.