Comparative muscle transcriptome associated with carcass traits of Nellore cattle
Bárbara Silva-Vignato1, Luiz L Coutinho2, Aline S M Cesar2
1College of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, 13635-900, Brazil. bsilvavignato@gmail.com.
BMC Genomics
|July 5, 2017
Summary
This study identified genes and pathways influencing ribeye area (REA) and backfat thickness (BFT) in Nellore cattle. Understanding these molecular processes can improve meat yield and carcass quality in beef production.
Area of Science:
- Animal Genomics
- Molecular Biology
- Beef Cattle Production
Background:
- Commercial meat yield is crucial for beef production value.
- Ribeye area (REA) and backfat thickness (BFT) are indirect measures of meat yield.
- These traits impact carcass yield, muscularity, and fat content.
Purpose of the Study:
- Investigate the Longissimus dorsi muscle transcriptome in Nellore cattle.
- Identify differentially expressed genes (DEGs) associated with REA and BFT.
- Uncover metabolic pathways and biological processes regulating these traits.
Main Methods:
- Compared gene expression between extreme genomic estimated breeding value (GEBV) groups.
- Utilized false discovery rate (FDR) for DEG identification.
- Performed functional enrichment analysis (KEGG pathways, biological processes).
Main Results:
- Identified 101 DEGs for REA and 18 DEGs for BFT.
- REA associated with MAPK signaling and endocytosis pathways.
- BFT related to adipogenesis and lipid biosynthesis pathways, with RSAD2 highlighted.
Conclusions:
- Identified key genes and pathways regulating muscle and fat deposition.
- Findings provide molecular insights into economically important carcass traits.
- Results contribute to understanding differentiation, proliferation, and hypertrophy in beef cattle.
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