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Storage of red blood cell concentrates: Clinical impact.

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The storage lesions: From past to future.

J-D Tissot1, M Bardyn2, G Sonego2

  • 1Transfusion interrégionale CRS, Laboratoire de Recherche sur les Produits Sanguins, 2, route de la Corniche, CH-1066 Epalinges, Switzerland; Faculté de biologie et de médecine, université de Lausanne, Lausanne, Switzerland.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|July 5, 2017
PubMed
Summary

Storage of red blood cells and platelets causes biochemical changes, impacting transfusion effectiveness. Further research is needed to clarify the clinical significance of these storage lesions.

Keywords:
AgeingBlood cellsMicroparticlesOxidationPlateletsProteomicsRed blood cellsStorageTransfusion

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Area of Science:

  • Transfusion Medicine
  • Biochemistry
  • Hematology

Background:

  • Red blood cell (RBC) and platelet concentrates (PCs) have specific storage conditions (4°C for RBCs, 22°C with agitation for PCs) impacting their quality.
  • Storage induces cellular damage and biochemical alterations, including protein modifications, some of which are irreversible.
  • The clinical impact of these storage lesions on transfusion outcomes remains debated, with some studies suggesting poorer patient outcomes with older blood products.

Purpose of the Study:

  • To enhance understanding of storage lesion development, focusing on biochemical modifications.
  • To stimulate discussion on advancing blood transfusion processes.
  • To advocate for an independent international organization to guide transfusion medicine research and practice.

Main Methods:

  • This is a review article, synthesizing existing research on blood product storage lesions.
  • Focuses on biochemical changes occurring during storage of RBCs and PCs.
  • Examines the link between storage-induced alterations and transfusion efficiency.

Main Results:

  • Storage leads to cellular damage and metabolic/protein alterations in RBCs and PCs.
  • Irreversible changes, particularly protein oxidation, may compromise blood component quality.
  • Evidence linking older blood products to poorer patient outcomes is suggestive but not definitively established.

Conclusions:

  • Storage lesions represent a significant area of concern in transfusion medicine.
  • Further research into biochemical modifications is crucial for improving blood product quality and transfusion efficacy.
  • Establishing evidence-based practices through controlled clinical studies is essential for transfusion medicine advancement.