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Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular

Yoshiaki Ohyama1, Bharath Ambale-Venkatesh1, Chikara Noda1

  • 1From the Department of Cardiology (Y.O., C.N., J.-Y.K., Y.T., G.T.-T., A.R.C., J.A.C.L.), Department of Radiology (B.A.-V.), and Department of Epidemiology (E.G.), Johns Hopkins University, Baltimore, MD; Imagerie Cardiovasculaire/Department of Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris (A.R.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (C.-Y.L., D.A.B.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).

Hypertension (Dallas, Tex. : 1979)
|July 5, 2017
PubMed

Insights

Aortic arch pulse wave velocity (PWV) measured by MRI predicts cardiovascular disease (CVD) events in middle-aged adults. This association was not found in older individuals, highlighting age-specific predictive value.

Area of Science:

  • Cardiovascular Imaging and Diagnostics
  • Vascular Biology and Atherosclerosis Research

Background:

  • The predictive capability of aortic arch pulse wave velocity (PWV) for cardiovascular disease (CVD) events remains incompletely understood.
  • Magnetic resonance imaging (MRI) offers a non-invasive method for assessing PWV.

Purpose of the Study:

  • To investigate the association between aortic arch PWV, measured via MRI, and the incidence of CVD events.
  • To determine if this association differs across age groups within the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Main Methods:

  • Utilized data from 3527 MESA participants without pre-existing CVD.
  • Measured aortic arch PWV using MRI at baseline.
  • Employed Cox regression analysis, adjusting for covariates, to assess incident CVD risk over a 10-year follow-up, stratifying by age (45-54 and >54 years).

Main Results:

  • A significant association was observed between higher aortic arch PWV and increased risk of incident CVD events in participants aged 45-54 years (HR 1.44, P=0.018 per 1-SD increase).
  • No significant association between aortic arch PWV and CVD events was found in participants older than 54 years (P=0.93).
  • 456 CVD events occurred during the follow-up period.

Conclusions:

  • Aortic arch PWV assessed by MRI is a significant independent predictor of incident CVD events in middle-aged adults (45-54 years).
  • The predictive value of aortic arch PWV for CVD events is age-dependent, being significant in middle-aged but not elderly individuals.

Keywords:
cardiovascular diseasescoronary artery diseaseheart failurepulse wave analysisvascular stiffness

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