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Icodextrin and peritoneal dialysis: advantages and new applications
Periklis Dousdampanis1, Carlos Guido Musso2, Konstantina Trigka3
1Hemodialysis Unit Kyanous Stavros Patras, Germanou 115, 26225, Patras, Greece. dousdampanis@yahoo.gr.
International Urology and Nephrology
|July 5, 2017
Summary
Icodextrin (ico) solutions enhance peritoneal dialysis (PD) effectiveness and patient survival, offering benefits like improved ultrafiltration and metabolic control, especially for high-transporter PD patients.
Area of Science:
- Nephrology
- Renal Replacement Therapy
Background:
- Icodextrin (ico) is established for peritoneal dialysis (PD) extension and survival.
- It's primarily used in high-transporter PD patients.
- Benefits include biocompatibility, reduced glucotoxicity, and improved ultrafiltration (UF).
Purpose of the Study:
- To review the impact and evolving strategies of icodextrin in peritoneal dialysis.
- To highlight new approaches for managing ultrafiltration failure and glucose exposure.
- To explore simplified PD schedules with icodextrin.
Main Methods:
- Literature review of icodextrin use in peritoneal dialysis.
- Analysis of new strategies: bimodal solutions and twice-daily ico exchanges.
- Evaluation of simplified PD schedules (single/two ico exchanges).
Main Results:
- Icodextrin improves UF, sodium removal, metabolic control, and blood pressure.
- New strategies address glucose exposure and UF failure in PD.
- Simplified ico schedules offer alternatives for fluid management in specific patient groups.
Conclusions:
- Icodextrin is a valuable tool in PD, offering significant patient benefits.
- Novel ico-based strategies enhance treatment efficacy and patient management.
- Simplified PD schedules with icodextrin present potential options for selected ESRD patients.
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