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Updated: Feb 27, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
Published on: June 13, 2025
Neuroglia: Functional Paralysis and Reactivity in Alzheimer's Disease and Other Neurodegenerative Pathologies
Alexei Verkhratsky1,2,3,4,5, Robert Zorec6,7, J J Rodriguez8,9
1Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK. Alexej.Verkhratsky@manchester.ac.uk.
Abstract:
The most notable finding in neurodegenerative diseases is the progressive death of neurones cells. Yet, neuroglial changes can precede and facilitate neuronal loss. This is perhaps expected because astroglial cells maintain the brain homoeostasis, and are responsible for defence and regeneration, so that their malfunction manifested as degeneration or asthenia together with reactivity contribute to pathophysiology. Neuroglia may represent a novel target for therapeutic intervention, be that prevention, slowing progression of or possibly curing neurodegenerative diseases.
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