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H + transport in urinary epithelia.

The American Journal of Physiology

|August 1, 1978

Summary

This summary is machine-generated.

This review suggests that hydrogen ion (H+) secretion drives bicarbonate absorption in the kidney. Key regulators include the electrochemical gradient, CO2, and aldosterone, with the pentose shunt fueling this crucial transport.

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Area of Science:

Physiology
Cell Biology
Renal Physiology

Background:

Urinary acidification is critical for maintaining acid-base balance.
The precise mechanisms of bicarbonate absorption and hydrogen ion (H+) transport in the kidney remain areas of active investigation.

Purpose of the Study:

To review the evidence for H+ secretion as the primary driver of bicarbonate absorption.
To discuss the regulatory mechanisms and metabolic pathways involved in renal H+ transport.

Main Methods:

Review of studies on isolated epithelia, primarily the turtle bladder.
Analysis of indirect evidence and experimental data on H+ transport regulation.
Examination of metabolic pathways fueling H+ transport.

Main Results:

Indirect evidence strongly suggests H+ secretion into the lumen causes bicarbonate absorption.
Electrochemical gradients, CO2, and aldosterone are identified as key regulators of H+ transport.
The pentose shunt is highlighted for its role in energizing H+ transport, alongside other major metabolic pathways.

Conclusions:

H+ secretion is the likely mechanism for bicarbonate absorption in the kidney.
Understanding H+ transport regulation and energetics is vital for renal physiology.
H+ transport plays a significant role in energy transduction within subcellular organelles.