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Published on: October 4, 2019
MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma
Kun Xue1,2, Junmei Yang3, Jia Hu2
1a Department of Neurosurgery , Qilu Hospital of Shandong University , Jinan , Shandong , China.
Background:
Recently, microRNA-133b (miR-133b) dysregulation has been shown to play a key role in several human cancers, as well as glioma. In this study, we aimed to investigate the clinical significance and prognostic value of miR-133b in glioma.
Methods:
Real-time quantitative PCR was employed to measure the expression level of miR-133b in tissues. Survival analysis was carried out by using the log-rank test and Kaplan-Meier method. Prognostic factors for overall survival were identified by univariate and multivariate analyses using the Cox proportional hazards regression model.
Results:
The expression level of miR-133b was significantly lower in glioma tissues compared with matched non-cancerous brain tissues (p < .05). Its level was strongly correlated with Karnofsky Performance Scale score (p < .001) and WHO grade (p < .001). Kaplan-Meier survival and log-rank analysis indicated that the decreased expression of miR-133b was strongly correlated with shorter overall survival of patients with glioma (log-rank test, p = .03).
Conclusions:
The current investigation demonstrated that miR-133b level is useful for predicting the prognosis of patients with glioma.
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