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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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Embryonic stem cells and the next generation of developmental toxicity testing

Josephine Kugler1, Bettina Huhse1, Tewes Tralau1

  • 1a Department of Chemical & Product Safety , German Federal Institute for Risk Assessment (BfR) , Berlin , Germany.

Expert Opinion on Drug Metabolism & Toxicology
|July 5, 2017
PubMed
Summary

Embryonic stem cells (ESCs) show promise for developmental toxicity testing, but routine use is premature due to biological limitations and validation needs. Further research and collaboration are essential for their regulatory implementation.

Keywords:
Embryonic stem cells (ESCs)developmental toxicity testingembryonic stem cell test (EST)induced pluripotent stem cells (iPSCs)

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