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Related Experiment Videos

Peptides and feeding.

J E Morley, A S Levine, B A Gosnell

    Peptides
    |January 1, 1985
    PubMed
    Summary
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    This review explores the role of peptides in appetite regulation, highlighting that current evidence is mainly pharmacological. Further research is needed to confirm their physiological significance in feeding behaviors.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Physiology

    Background:

    • Peptides are hypothesized to influence appetite control.
    • Existing evidence primarily stems from pharmacological studies.
    • The physiological relevance of these findings requires careful consideration.

    Purpose of the Study:

    • To review the hypothesis linking peptides to appetite modulation.
    • To discuss proposed peripheral satiety and central feeding peptide systems.
    • To examine the role of peptides in aging anorexia and feeding-related autonomic effects.

    Main Methods:

    • Literature review of pharmacological and physiological studies on peptides and appetite.
    • Analysis of proposed peptide systems involved in satiety and feeding.

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  • Discussion of peptide involvement in specific physiological contexts.

    • Main Results:

    • Pharmacological evidence suggests peptides influence appetite.
    • Two main peptide systems are proposed: peripheral satiety (e.g., cholecystokinin) and central feeding (opioid peptides, neuropeptide Y).
    • Peptides may play roles in age-related anorexia and feeding-induced autonomic responses.

    Conclusions:

    • While pharmacological data is suggestive, caution is advised regarding the physiological significance of peptides in appetite modulation.
    • Further investigation is necessary to elucidate the precise in vivo roles of these peptide systems.
    • Peptides are implicated in complex feeding behaviors and associated physiological effects.