Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alveoli and Alveolar Ducts01:26

Alveoli and Alveolar Ducts

6.2K
The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
6.2K
Cellular Differentiation00:57

Cellular Differentiation

5.8K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.8K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.7K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.9K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

950
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
950
General Transcription Factors01:30

General Transcription Factors

7.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practical Guidelines for Asthma Management (PGAM): Digest edition.

Respiratory investigation·2025
Same author

Real-world safety and effectiveness of mepolizumab for patients with eosinophilic granulomatosis with polyangiitis in Japan: Long-term observation of the MARS study.

Modern rheumatology·2024
Same author

Case of colon perforation due to segmental absence of intestinal musculature accompanied by cancer treated with colonic resection and anastomosis.

Surgical case reports·2024
Same author

STING/RANTES pathway in airway epithelium enhances Der p1-induced airway inflammation.

Allergy·2024
Same author

Real-world safety and effectiveness of mepolizumab for patients with eosinophilic granulomatosis with polyangiitis in Japan: A 48-week interim analysis of the MARS study.

Modern rheumatology·2023
Same author

FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation.

Molecular metabolism·2023

Related Experiment Video

Updated: Feb 27, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.4K

Foxc2 influences alveolar epithelial cell differentiation during lung development.

Mayoko Tsuji1, Masae Morishima2, Kazuhiko Shimizu2

  • 1First Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan.

Development, Growth & Differentiation
|July 5, 2017
PubMed
Summary

Forkhead box protein C2 (FOXC2) is crucial for lung development, as Foxc2 knockout mice exhibit smaller lungs with impaired alveolar and capillary development. This study reveals FOXC2

Keywords:
Foxc2Lef1alveolar progenitor celllung developmentmouse

More Related Videos

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

7.8K
Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures
08:42

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

4.2K

Related Experiment Videos

Last Updated: Feb 27, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.4K
Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

7.8K
Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures
08:42

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

4.2K

Area of Science:

  • Developmental Biology
  • Genetics
  • Respiratory Medicine

Background:

  • FOXC2 is a transcription factor linked to congenital heart disease, lymphedema-distichiasis, and yellow nail syndrome.
  • Its role in lung development has not been previously reported.

Purpose of the Study:

  • To investigate the morphological characteristics of lung development in Foxc2-knockout mouse models.
  • To elucidate the relationship between FOXC2 and lung morphogenesis.

Main Methods:

  • Analysis of ICR-Foxc2 knockout mouse fetuses at embryonic days 10.5-18.5.
  • Morphological assessment of lung tissues.
  • Expression analysis of Foxc2 and Lef1 in wild-type and knockout lungs.

Main Results:

  • Foxc2-knockout lungs were significantly smaller and parenchymatous compared to wild-type.
  • Impaired alveolar development observed, with distant capillary beds and altered alveolar cell differentiation (reduced type 2, thicker type 1 cells).
  • Foxc2 expression localized to lung mesenchyme early in development; Lef1 expression was inhibited in knockout lungs.

Conclusions:

  • FOXC2 plays a critical role in lung development, influencing alveolar epithelial cell differentiation and capillary-alveolar epithelial interactions.
  • Abnormalities in Foxc2 knockout mice suggest roles in lymph vessel malformation and lung morphogenesis.
  • This Foxc2 knockout model offers insights into respiratory disease mechanisms.