Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [<sup>68</sup>Ga]Ga-TEoS-DAZA.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Comparative Analysis of Regional Blood-Brain Barrier Permeability in Humans and Rodents: An Evolutionary Perspective.

Research square·2026
Same author

Paroxysmal slow waves mark ictal networks.

Epilepsia·2026
Same author

Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis.

Communications biology·2026
Same author

The modified Hijdra scale for prediction of delayed cerebral infarcts after subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Retinal Vessel Dysfunction in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: An Ultra-Widefield Fluorescein Angiography Study.

Neurology open access·2026

Related Experiment Video

Updated: Feb 27, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K

Neuroinflammation imaging markers for epileptogenesis.

Matthias J Koepp1, Eric Årstad2, Jens P Bankstahl3

  • 1Institute of Neurology, University College London, London, United Kingdom.

Epilepsia
|July 5, 2017
PubMed
Summary

Preventing epilepsy requires identifying at-risk patients and understanding epileptogenesis. Early biomarkers are crucial for treatment response and insight into disease development following brain insults.

Keywords:
Blood-brain barrierEpileptogenesisGliaMagnetic resonance imaging (MRI)Nuclear medicine imaging (PET/SPECT)

More Related Videos

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.6K
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

13.3K

Related Experiment Videos

Last Updated: Feb 27, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.6K
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

13.3K

Area of Science:

  • Neuroscience
  • Neurology
  • Epilepsy Research

Background:

  • Epilepsy is a severe neurological disorder causing seizures, cognitive, and emotional impairments, significantly reducing quality of life.
  • Epilepsy often develops after a latent period (epileptogenesis) following brain insults like trauma or stroke.

Purpose of the Study:

  • To identify and detect processes responsible for epilepsy onset, aiming for prevention.
  • To monitor and treat epilepsy progression.
  • To establish methods for stratifying patients at risk for long-term epilepsy and identify early biomarkers for treatment response and disease mechanisms.

Main Methods:

  • The study focuses on the latent period of epileptogenesis as a therapeutic window.
  • It emphasizes the need for risk stratification and biomarker development.

Main Results:

  • Current inability to stratify patients at risk for long-term epilepsy hinders preventative clinical trials.
  • The long latent period highlights the value of early biomarkers for treatment response.
  • Mechanistic biomarkers of epileptogenesis can offer deeper insights into disease development.

Conclusions:

  • Developing methods to identify at-risk individuals is essential for epilepsy prevention.
  • Early and mechanistic biomarkers are critical for effective epilepsy management and research.