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Therese E Wilbek1, Rasmus B Jansen1, Bo Jørgensen2

  • 1Department of Endocrinology, University of Copenhagen, Bispebjerg Hospital, Denmark.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|July 5, 2017
PubMed
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Early death risk factors for diabetes patients undergoing lower ankle amputations include high age and arterial insufficiency. Prompt amputation after admission increases mortality, while statin use may decrease it.

Area of Science:

  • Diabetes Mellitus Research
  • Vascular Surgery Outcomes
  • Public Health Epidemiology

Background:

  • Diabetes is a leading cause of lower extremity amputations.
  • Identifying mortality risk factors in this patient population is crucial for improving outcomes.

Purpose of the Study:

  • To determine risk factors associated with early mortality in diabetic patients undergoing below-ankle amputations.

Main Methods:

  • Retrospective study of diabetic patients undergoing below-ankle amputations (1996-2013).
  • Analysis included trans-metatarsal and toe amputations.
  • Minimum 5-year follow-up data analyzed.

Main Results:

  • 5-year mortality rates were 42% for type 2 diabetes and 29% for type 1 diabetes.

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  • For type 2 diabetes, increased mortality was linked to high age, peripheral arterial insufficiency, and shorter time from admission to amputation.
  • Statin use was associated with reduced mortality.

    • Conclusions:

    • Short time from first admission to amputation is a significant risk factor for early death.
    • High age and arterial insufficiency are associated with increased mortality in type 2 diabetes patients.
    • Statin therapy may offer a protective effect, reducing mortality risk.