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Related Concept Videos

Nuclear Protein Sorting01:34

Nuclear Protein Sorting

6.5K
Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
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Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

3.4K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

5.5K
5.5K
Nuclear Export01:42

Nuclear Export

5.1K
The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
5.1K
Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

8.0K
Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
8.0K

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Related Experiment Video

Updated: Feb 27, 2026

Single-Molecule Imaging of Nuclear Transport
12:13

Single-Molecule Imaging of Nuclear Transport

Published on: June 9, 2010

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Nuclear pore complex tethers to the cytoskeleton.

Martin W Goldberg1

  • 1Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.

Seminars in Cell & Developmental Biology
|July 6, 2017
PubMed
Summary
This summary is machine-generated.

The nuclear envelope connects to the cell

Keywords:
CytoskeletonMicrotubuleNuclear envelopeNuclear poreNup358RanBP2

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Area of Science:

  • Cell Biology
  • Cytoskeletal Dynamics
  • Molecular Motors

Background:

  • The nuclear envelope anchors to the cytoskeleton via the LINC complex.
  • Nuclear pore complexes (NPCs) facilitate molecular transport.
  • Microtubules form a key part of the cytoskeleton.

Purpose of the Study:

  • To explore the linkage between nuclear pore complexes and the microtubule network.
  • To discuss the roles of these linkages in cellular functions.

Main Methods:

  • Review of existing literature on cytoskeletal-nuclear envelope interactions.
  • Analysis of the molecular mechanisms connecting NPCs to microtubules.

Main Results:

  • NPCs link to microtubules via motor proteins (dynein, kinesins).
  • The adaptor BicD2 is crucial for linking motor proteins to Nup358 on NPCs.
  • Evidence supports roles in nuclear migration, cell cycle, and architecture.

Conclusions:

  • NPCs are actively linked to the microtubule cytoskeleton.
  • This linkage, mediated by motor proteins and adaptors, influences fundamental cellular processes.