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Peritoneal Dialysis for Patients with Autosomal Dominant Polycystic Kidney Disease

Sana Khan1, Anna Giuliani2, Carlo Crepaldi2

  • 1Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia, USA.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|July 6, 2017
PubMed

Insights

Peritoneal dialysis (PD) is a safe and effective renal replacement therapy for patients with autosomal dominant polycystic kidney (ADPKD) disease. Outcomes with PD in ADPKD patients are comparable or superior to other patient groups, dispelling concerns about fluid tolerance.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Genetics

Background:

  • Autosomal dominant polycystic kidney (ADPKD) disease frequently leads to end-stage renal disease (ESRD).
  • Peritoneal dialysis (PD) is a potential renal replacement therapy for ESRD patients.
  • Concerns exist regarding fluid volume tolerance in PD for ADPKD patients.

Purpose of the Study:

  • To review the existing data on outcomes and complications of PD in ADPKD patients.
  • To evaluate the safety and efficacy of PD for ADPKD.
  • To inform clinical practice regarding PD use in ADPKD.

Main Methods:

  • Literature review of studies on PD in ADPKD patients.
  • Analysis of outcomes and complication data.
  • Comparison of PD outcomes in ADPKD versus other patient groups.

Main Results:

  • PD is generally well-tolerated in ADPKD patients.
  • Fluid volume tolerance is not a significant barrier to PD in this population.
  • Outcomes for ADPKD patients on PD are equivalent to or better than other patient groups.

Conclusions:

  • PD is a viable and effective treatment option for ESRD secondary to ADPKD.
  • Concerns about fluid intolerance should not preclude PD consideration in ADPKD.
  • PD offers comparable or improved outcomes for ADPKD patients requiring renal replacement therapy.

Keywords:
Peritoneal dialysisautosomal dominant polycystic kidney diseasecomplications

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