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Updated: Feb 27, 2026
Mouse Oocyte Microinjection, Maturation and Ploidy Assessment
Published on: July 23, 2011
Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos
Jingye Zhang1,2,3, Wenrong Tao1,2,3, Hui Liu1,2,3
1Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, Jinan, 250021, China.
Purpose:
This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status.
Methods:
Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subjected to trophectoderm biopsy and microarray comparative genomic hybridization (array-CGH). Blastocyst development process was analyzed using time-lapse images.
Results:
Morphokinetic parameters: tPNf, t2, t3, t4, t5, t8, t9, tcom, tM, tSB, tB, tEB, CC1, CC2, CC3, S2, S3, t5-t2, and tB-tSB showed no significant difference in euploid embryos compared to aneuploid counterparts. In addition, two risk models based on previously published morphokinetic parameters failed to segregate euploid from aneuploid embryos.
Conclusions:
Morphokinetic parameters subjected to investigation in the present study failed to improve the chance of selecting euploid embryos.
